International Journal of Applied Research
Vol. 1, Issue 11, Part O (2015)
Tanacetum Parthenium: Medicinal Applications
Mandeep kaur, Mayank sharma
Tanacetum parthenium is a medicinal herb which is used to cure many of the prevailing incurable diseases. It is commonly known as feverfew plant. An organic compound named as ‘parthenolide’ is extracted from feverfew plant which is of great medicinal and therapeutic importance. The parthenolide and sesquiterpene lactone isolated from feverfew has been successful in curing diseases like migraine, apoptosis of breast cancer cells, antileishmanial activity, neurogenic vasodilation, rheumatoid arthritis, platelet production cum activation and many more. The parthenolide for curing migraine acts upon the TRPA1 channels, which acts as stimulant to trigger migraine attacks, inactivates the TRPA1 channels ad makes the nerve unresponsive towards these channel. The apoptosis mediated cytotoxic effect of parthenolide on breast cancer cell line is attributed to the presence of α-methylene-Υ-lactone skeleton. It is the occurrence of lactone skeleton which leads to apoptosis of cancer cells. It has been examined that in vitro conditions allow the production of platelets from human megakaryocyte cell line, the platelet production is achieved via inhibiting nuclear factor-kB signalling in the megakaryocytes by the action of parthenolide. The parthenolide is a sesquiterpene lactone which inhibits the growth of Leishmania amazonensis. The sesquiterpene is made up of three isoprene and one lactose group attached to it. Using the organic components of feverfew plant- ‘parthenolide’ and ‘sesquiterpene lactone we can surely combat the frightening diseases emerging in the world. The use of feverfew must be encouraged as the production of medicines from it is a less hectic task. Although parthenium is an exotic variety of weed in India but its species have an incredible quality for saving the life of people.
How to cite this article:
Mandeep kaur, Mayank sharma. Tanacetum Parthenium: Medicinal Applications. International Journal of Applied Research. 2015; 1(11): 1030-1031.