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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

Impact Factor: RJIF 5.2

International Journal of Applied Research

Vol. 1, Issue 2, Part C (2015)

Evaluation of anti-inflammatory activity of ethanolic extract of leaves of Clerodendrum serratum Linn. in experimental animals

Author(s)
Malik Tafazul Rashid, Shabir A Lone, Sajad H Wani and AS Yadav
Abstract
The present study was conducted to evaluate the anti-inflammatory activity of Clerodendrum serratum Linn. The anti-inflammatory activity was done by in-vivo model i.e. the carrageenan induced rat paw edema model. The standard drug diclofenac sodium (500mg/kg) has significantly reduced paw oedema volume by0.15±0.02 at 1st hr, 0.18±0.01 at2nd hr, 0.25 ±0.02 at 3rd hr and 0.3 at±0.02 at 4th hr, thus standard drug has exhibited time dependent reduction in oedema volume. The ethanolic extract with a dose of 200mg/kg b.w has significantly reduced oedema volume by 0.18±0.03, 0.25 ±0.0.02, 0.28. ±0.01, 0.35±0.03 at 1st, 2nd, 3rd and 4th hrs respectively which was found to be a time dependent effect. At the end of 4 hours in test group treated with 200mg/kg b.w of ethanolic extract showed inhibitory effects of 37.5% respectively.
Pages: 165-168  |  216 Views  1 Downloads
How to cite this article:
Malik Tafazul Rashid, Shabir A Lone, Sajad H Wani and AS Yadav. Evaluation of anti-inflammatory activity of ethanolic extract of leaves of Clerodendrum serratum Linn. in experimental animals. International Journal of Applied Research. 2015; 1(2): 165-168.
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