International Journal of Applied Research
Vol. 1, Issue 8, Part I (2015)
Orchidectomy as the Primary Therapy in Patients with Advanced Carcinoma of the Prostate: A Ten Year Experience in Maiduguri North Eastern Nigeria
AG Ibrahim, S Aliyu, HM Dogo, MB Tahir, AB Zarami
Background: Prostate cancer is one of the commonest malignancies affecting males. Hormonal manipulation offers the best treatment for advanced disease. In developing countries orchidectomy provides simple and cost effective option. Patients and Methods: The study reviewed all patients with advanced carcinoma of the prostate managed between January 2004 and December 2013. All patients had orchidectomy.Patients with castration – resistant disease were offered anti-androgens. Results: A total of 222 patients were studied age ranged from 45 to 90 years, with mean age of 67.5 years. The mean PSA was 34.8ng/ml with a range of 21 to 127ng/ml at presentation. Complications at presentation were impaired renal function 24.32% and paraplegia 13.06%. Locally advanced diseases were in 66.67%. Metastatic diseases were in 33.33%. Orchidectomy conferred tumour regression with clinical improvement from 48 hours to 24 months with a mean of 18 months. The median overall survival was 30 months with a 5 year survival of 13.06%. Disease progression despite orchidectomy was seen in 4.05%. Castration resistance (escape phenomenon) begun to develop 18 months post orchidectomy evidenced by rising PSA from castrate level (nadir PSA), and or clinical symptoms. Nadir PSA mean was 8.7ng/ml. A total of 48.20% had PSA nadir of <4ng/ml.rnConclusion: Carcinoma of the prostate is a common disease often with patients presenting late with advanced disease associated with complications. Orchidectomy offers time – tested benefits, it is simple, acceptable, and cost effective.
How to cite this article:
AG Ibrahim, S Aliyu, HM Dogo, MB Tahir, AB Zarami. Orchidectomy as the Primary Therapy in Patients with Advanced Carcinoma of the Prostate: A Ten Year Experience in Maiduguri North Eastern Nigeria. International Journal of Applied Research. 2015; 1(8): 515-517.