Vol. 1, Issue 8, Part I (2015)

Abstract
Background- In this study, we tried to find out insulin resistance in chronic kidney disease in its various stages. Material and Methods- This study was conducted in 100 chronic kidney disease patients (both inpatient and outpatient) in the Department of General Medicine, GRMC Gwalior during the period from August 2011- October 2012. Data was collected using a standardized questionnaire, personal interview, physical examination and biochemical investigations. Results- In our study 100 patients were taken, 57% of the patients were males and 43% were females) with mean age of 44.2 years. The majority of the patients in the study group presented with vomiting and edema. Insulin resistance demonstrated an ascending pattern of prevalence as 27.6%, 31.1%, and 41.4% in stage 3, stage 4, and stage 5 chronic kidney disease respectively. More than half of the hyperinsulinemic patients in stage 5 were overweight). Proteinuria was present in 8 patients out of 9 (88.8%) in stage 4 and 8 out of 12 (66.7%) in stage 5 insulin resistant patients. Conclusion- Insulin resistance was found in the patients of chronic kidney disease in ascending pattern from stage 3 to 5.