International Journal of Applied Research
Vol. 1, Issue 9, Part I (2015)
Original Article - Level of serum free testosterone in male patients presenting with acute coronary syndrome
Sanjay Dhawale, Rakesh Gaharwar, Satyam Singh Jayant
Aims and objectives- To study clinical profile of acute coronary syndrome and to study the the role of testosterone in patients of acute coronary syndrome. Material and methods-50 cases of ACS and 25 healthy controll males were included in the study done in in J.A. Group of Hospitals Gwalior. Detail history, clinical examination, laboratory investigations as required and Ecg was done after written concent. Data Was Filled in Preformed Proforma and then statistical analysis is as per results shown here. Results- The present study included 50 patients who presented with acute coronary syndrome and 25 patients of age matched controls without evidence of CAD. In the study group, the mean age of presentation was 53.3 yrs. The commonest presenting symptom was chest pain followed by palpitation. Hypertension present in 34% of cases and 28% of controls. Smoking incidence was 46% in cases and 20% in controls. Higher levels of total cholesterol, triglyceride and LDL cholesterol and lower level of HDL cholesterol were seen in cases. They significantly differ in comparison to controls. Of the cases studied, about 86% had STEMI and 14% had NSTEMI. The mean serum free testosterone was significantly lower in patients with ACS. Serum free testosterone level was also significantly lower in patients with hypertension and smokers. Mean serum free testosterone level did not relate to the number of cardiovascular risk factors. Most of the patients (48%) presented with AWMI followed by IWMI (32%). Mean serum free testosterone level was lowest in patient who had IWMI+AWMI as compared with other patterns of ACS. Of the 50 cases studied, 2 patients died (percentage of mortality - 4%).Mean serum free testosterone level was inversely related to hypertension, dyslipidemia, smokers and BMI. Conclusion- The serum free testosterone was found to be lower in patients with acute coronary syndrome as compared to controls. The difference between cases and controls was statistically significant. The serum free testosterone level was lowest in patients who presented with AWMI+IWMI as compared with other patterns of ACS. The serum free testosterone level was found to be lower in cases with traditional risk factors like smoking, hypertension, dyslipidemia and BMI.
How to cite this article:
Sanjay Dhawale, Rakesh Gaharwar, Satyam Singh Jayant. Original Article - Level of serum free testosterone in male patients presenting with acute coronary syndrome. International Journal of Applied Research. 2015; 1(9): 550-554.