Vol. 2, Issue 1, Part G (2016)

Abstract
The present investigation was carried out to find the effect of aqueous extract of leaves of Clerodendrum serratum Linn. for antiinflammatory activity in rodents. The aqueous extract of Clerodendrum serratum Linn. With a selected dose of 200mg/kg b.w have exhibited a significant reduction in paw oedema volume in carrageenan induced paw oedema in rats at different time intervals. The standard drug diclofenac sodium (500mg/kg) has significantly reduced paw oedema volume by 42.30% at 1^st hr, 45.45% at 2^nd hr, 41.86% at 3^rd hr and 46.42% at 4^th hr, thus standard drug has exhibited time dependent reduction in oedema volume. The ethanolic extract with a dose of 200mg/kg b.w has significantly reduced oedema volume by 11.53%, 15.15%, 23.25% and 28.57.% and 19.14% at 1^st, 2^nd, 3^rd and 4^th hrs respectively which was found to be a time dependent effect. At the end of 4 hours in test group treated with 200mg/kg b.w of aqueous extract showed inhibitory effects of 28.57% respectively.