Vol. 2, Issue 10, Part K (2016)

Material and Methods: We studied the level of Serum Urea, Creatinine, Urinary Albumin-Creatinine Ratio (ACR), 24 hours Urine Protein and Serum Cystain C) in SLE without nephritis and Lupus Nephritis patients. Any change after 6 months was noted and correlation of Serum Cystatin C with disease activity scores (SLEDAI) was done.

Results: Comparison of Serum Cystatin C level in the cases showed higher value at the first visit (2.50 ± 1.21) judge against the follow up visit at 6 months (1.03 ± 0.47). This variation was found statistically significant (P value < 0.001). Comparison of Serum Cystatin C level at first visit showed higher value in cases group (2.50 ± 1.21) compared to control (0.70 ±0.26) group. This difference was highly statistically significant (P value <0.001). Mean age of the study participant in the cases group was found 30.43 ± 7.29 years (ranging from 18 to 52 years) where as it was 29.85 ± 9.22 years (ranging from 18 to 58 years) in the control group.

Conclusion: Serum level of Cystatin C among adult Lupus Nephritis patients were higher than adult Non-renal SLE patients and can be used as a prognostic marker and may guide the treatment.