Vol. 2, Issue 12, Part K (2016)

Abstract
Stability constant is an effective parameter in pharmacodynamics and pharmacokinetic study of molecules. The medicinal properties of any molecule are checked after synthetic process for that various physical methodologies are used. Late work highlight pH-metric investigation of proton-ligand and metal-ligand stability constant of 2-p-Chlorophenylthiocarbamidophenol with various transition metal ion at 0.1 M ionic strength in 70% ethanol-water mixture by Irving-Rossotti method. It is observed that different transition metal ions forms 1:1 complex with 2-p-Chlorophenyl -thiocarbamidophenol. The information acquired was used to estimate and compare the values of proton –ligand stability constant (pK) and metal-ligand stability constants (logk). The effects of substituent’s were studied from the evaluated information (pK and logk).