Vol. 2, Issue 4, Part F (2016)

Abstract
Kinetics of the complexation of Ni(II) with DL-2-Amino butanoicacid and Acetyl L-histidine was studied in the pH range 6.03-7.18 at 620 nm using bromothymol blue as indicator, under first order conditions. The overall rate constant was resolved into stepwise rate constant and corresponding activation parameters were also determined. Negative value of entropy of activation predicts associatively activated mechanism. These amino acids are excreted in urine in certain genetic disorders. Chelation with metal ions may open new avenues for detecting these metabolic disorders.