International Journal of Applied Research
Vol. 2, Issue 4, Part H (2016)
Strain improvement of Aspergillus niger to increase lovastatin production
Dr. Abboud Y ElKichaoui
The aim of the improvements in the present research was to develop strain with improved traits and to enhance lovastatin production. The process of strain improvement of Aspergillus niger involved UV irradiation treatment in addition to improvements in the production conditions, that is, the type and concentration of carbon and nitrogen sources in the production medium. The improved strain exhibited lovastatin productivity many folds higher than that of the wild strain. The effect of lovastatin on total blood cholesterol and triglycerides has been conducted using ordinary normal rabbits with high cholesterol feed which showed a significant reduction of both total blood cholesterol and triglycerides levels. Lovastatin was analyzed by UV spectrophotometer and thin layer chromatography (TLC).
How to cite this article:
Dr. Abboud Y ElKichaoui. Strain improvement of Aspergillus niger to increase lovastatin production. International Journal of Applied Research. 2016; 2(4): 501-503.