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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

Impact Factor: RJIF 5.2

International Journal of Applied Research

Vol. 2, Issue 4, Part H (2016)

Strain improvement of Aspergillus niger to increase lovastatin production

Author(s)
Dr. Abboud Y ElKichaoui
Abstract
The aim of the improvements in the present research was to develop strain with improved traits and to enhance lovastatin production. The process of strain improvement of Aspergillus niger involved UV irradiation treatment in addition to improvements in the production conditions, that is, the type and concentration of carbon and nitrogen sources in the production medium. The improved strain exhibited lovastatin productivity many folds higher than that of the wild strain. The effect of lovastatin on total blood cholesterol and triglycerides has been conducted using ordinary normal rabbits with high cholesterol feed which showed a significant reduction of both total blood cholesterol and triglycerides levels. Lovastatin was analyzed by UV spectrophotometer and thin layer chromatography (TLC).
Pages: 501-503  |  521 Views  16 Downloads
How to cite this article:
Dr. Abboud Y ElKichaoui. Strain improvement of Aspergillus niger to increase lovastatin production. International Journal of Applied Research. 2016; 2(4): 501-503.
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