Vol. 2, Issue 6, Part P (2016)

Abstract
The aim of this study was to apply and evaluate usefulness Central Composite design for the optimization of polymer concentration in sustained release tablets of muscle relaxant Baclofen. Drug release at 4 hrs (R4_hrs) and 12 hrs (R12_hrs) were taken as target responses, whereas the concentration of different polymers such as Polyox WSR 303 (hydrogel) and HPMC K4M (hydrophilic matrix system) were considered as impacting factors. A second-order polynomial equation was concluded using the multiple regression analysis for the experimental data. The design space was established targeting the successful operating ranges for drug release at 4 hrs (R4_hrs) and 12 hrs (R12_hrs) as 30.0-40.0% and 90.0-100.0% respectively. The design space illustrated that the available operation range is wide at the laboratory scale and thus ensuring the product quality. From the results of study it was concluded that successful application of central composite design of experiments is helpful to select grade and concentration of polymers cost effectively to reduce cost of goods which ultimately can improve profitability of pharmaceutical production unit.