International Journal of Applied Research
Vol. 2, Issue 7, Part D (2016)
Research article on formulation and evaluation of ramipril fast mouth dissolving tablet
Pant Madan, Singh Vikram, Juyal Divya, Rawat Geeta and Awasthi Deepak
The aim of present study was to formulate and evaluate fast mouth dissolving tablets of ramipril for the treatment of hypertension. In the present study the fast mouth dissolving tablets were prepared by direct compression by using various proportions of different superdisintegrants. To achieve the desired dissolution profile, sublimating agent like camphor was used. The uncoated tablets were evaluated for hardness, thickness, friability, weight variation, drug content, and disintegration time and in-vitro drug release. In-vitro drug release was found to be 99.05% from uncoated tablets in 33 min. FT-IR spectra revealed that there is no chemical incompatibility between the drug and other excipients. The results concluded the programmable pulsatile release has been achieved from uncoated tablets after a lag time of 33 min, which is consistent with the demands of the FMDTs drug delivery and increasing bioavailability.
How to cite this article:
Pant Madan, Singh Vikram, Juyal Divya, Rawat Geeta and Awasthi Deepak. Research article on formulation and evaluation of ramipril fast mouth dissolving tablet. International Journal of Applied Research. 2016; 2(7): 231-235.