Vol. 3, Issue 11, Part A (2017)

Abstract
Medicinal plants besides therapeutic agents are also a big source of information for a wide variety of chemical constituents which could be developed as drugs with precise selectivity. This study was intended to evaluate the anti-cancerous activity of chloroform and ethyle acetate extract of Solanum nigrum L. whole plant on the human melanoma cancer cell lines (A375).The percentage viability of cancer cell lines was carried out by using trypan blue dye exclusion method and cytotoxicity assay was screened by applying MTT [3-(4, 5-Diamethylthiazol-2-yl)-2,5-Diphenyl tetrazolium Bromide] assay. Solanum nigrum L. chloroform extract has depicted momentous and potent cytotoxic effect on A375 cell lines with IC₅₀ 346µg/ml in concentration ranging between 50μg/ml to 750μ/ml and acted as best agent to reduce the number of cancer cells to minimum. Further studies are needed to better characterize the mechanism of action underlying the beneficial effects of this alkaloid on their pathologies. Hence Solanum nigrum L. can be considered to be important to further investigate on molecular level to ascertain mechanism of action for said activity.