Vol. 3, Issue 12, Part D (2017)

Abstract
Chronic kidney diseases (CKDs) are a global burden and now a day’s it’s recognized as a foremost public health issue worldwide. Patients with CKD have variation in thyroid hormone metabolism. This study aims to evaluate the status of thyroid hormone profile in different stages of CKD and find out the correlation if any between thyroid dysfunction and severity of renal diseases. A prospective observational study was carried out on 100 patients with Chronic Kidney Disease on conservative management. Quantitative determination of T3, T4, TSH was done by ELISA and its data were analysed. Out of 100 patients, 48 patients had low T3 syndrome which accounts for 48% of the patients. 22 patients had low T4 syndrome (0.5-9.5µg/ml, mean 5.631) which accounts for 22% of the patients and 10 patients had primary hypothyroidism TSH >20µIU/ml. Excluding Primary Hypothyroidism, analysis of serum T3,T4 and TSH in the study subjects shows very high significance χ2 = 20.82, p < 0.001. In patients with low T3 syndrome, the mean values of TSH in various stages of renal disease are within normal range mean 4.85, values of TSH did not show any linear correlation with GFR. Number of patients with low T4 syndrome did not correlate with severity of renal disease. Thyroid Dysfunction occurred in 58% of the patients with chronic kidney disease in our study. The low T3 province of CKD can be seen as being defensive, advancing preservation of protein. The quantity of patients with low T3 disorder dynamically increments with the seriousness of renal failure.