International Journal of Applied Research
Vol. 4, Issue 3, Part C (2018)
Clinical and bacteriological profile of neonatal septicemia in a tertiary care hospital
Dr. Archana P Nikam and Dr. Pramod R Bhise
Neonatal sepsis is a clinical syndrome characterized by signs and symptoms suggestive of infection with or without accompanying bacteremia in the first month of life. Since the spectrum of organisms that cause neonatal sepsis changes over the time and varies from region to region and hospital to hospital even in the same city/country, it is necessary to conduct periodic surveillance to access the changing pattern of organisms causing neonatal sepsis. The present study was undertaken to know the clinical and bacteriological profile and an¬tibiotic susceptibility pattern of neonatal septicemia.
Methods: Total 251 samples received during the study period were processed as per standard bacteriological techniques and antibiotic susceptibility is performed as per CLSI guidelines.
Results: Out of 251 samples received during the study period, 142 (56.57%) were found to be positive. Prematurity (p < 0.05), birth asphyxia (p < 0.01) and duration of labor more than 24 hours (p < 0.05) were statistically significantrisk factors for causation of early onset septicemia. Refusal of feed, lethargy and weak reflexes were most common clinical presentation. 86 (60.56%) and 56 (39.44%) neonates had Gram positive and Gram negative infection respectively. Staphylococcus aureus and Klebsiella pneumoniae were the commonest isolates. Gram positive organisms were found to be sensitive to linezolid, and vancomycin and gram negative isolates were sensitive to meropenem and piperacillin tazobactam.
Conclusions: The periodic surveillance of etiological agents and their susceptibility pattern should be done in order to use better choice of antibiotics, as the patterns of bacterial organisms are changing constantly with time and place.
How to cite this article:
Dr. Archana P Nikam and Dr. Pramod R Bhise. Clinical and bacteriological profile of neonatal septicemia in a tertiary care hospital. International Journal of Applied Research. 2018; 4(3): 174-178.