Patients with CKD have an increased risk for cardiovascular disease. Since dyslipidemia, a major risk factor for coronary heart disease, an early detection and intervention for any alterations in the lipid profile of these patients will possibly help to prevent cardiovascular complications and rapid progression of renal failure.
• To determine the pattern of dyslipidemia in non-diabetic CKD patients on hemodialysis.
• Correlation between lipid profile and magnesium in non-diabetic chronic kidney disease patients on hemodialysis.
Methods: It is an observational cross sectional study in 100 subjects in which 50 are apparently healthy, remaining are non-diabetic CKD patients on hemodialysis. An estimation of total cholesterol, triglycerides, serum HDL, VLDL and serum magnesium will be done by enzymatic method by using an autoanalyser in S.R.G hospital Jhalawar. Cardiovascular risk indices (TC/HDL-C and LDL/HDL-C) were also determined.
Results: CKD was seen in all age groups with a mean age of 41.5 years and predominantly in males (68%).The mean triglyceride level (P<0.0001) higher than the control while HDL-C was significantly lower (P<0.0001). Cardiovascular risk indices TC/HDL-C, LDL-C/HDL-C were higher than the control. Serum magnesium level was significantly negatively correlated with serum triglycerides.
Conclusion: The abnormalities of lipid metabolism, such as hyper-triglyceridemia and low HDL-C, were associated with a low level of magnesium, could contribute to accelerated atherosclerosis and cardiovascular disease in hemodialysis patients.