International Journal of Applied Research
Vol. 5, Issue 1, Part C (2019)
An insight of a functional synapse - focused from a computational and experimental viewpoint
Dr. Amitabha Kar, Dr. Partha Majumder and Debraj Nandi
Neuronal communication is tightly regulated in time and in space. The neuronal transmission takes place in the nerve terminal, at a specialized structure called the synapse. Following neuronal activation, an electrical signal triggers neurotransmitter (NT) release at the active zone. The process starts by the signal reaching the synapse followed by a fusion of the synaptic vesicle and diffusion of the released NT in the synaptic cleft; the NT then binds to the appropriate receptor, and as a result, a potential change at the target cell membrane is induced. The entire process lasts for only a fraction of a millisecond. An essential property of the synapse is its capacity to undergo biochemical and morphological changes, a phenomenon that is referred to as synaptic plasticity.
In this survey, we consider the mammalian brain synapse as our model. We take a cell biological and a molecular perspective to present fundamental properties of the synapse: (i) the accurate and efficient delivery of organelles and material to and from the synapse; (ii) the coordination of gene expression that underlies a particular NT phenotype; (iii) the induction of local protein expression in a subset of stimulated synapses. We describe the computational facet and the formulation of the problem for each of these topics.
Predicting the behavior of a synapse under changing conditions must incorporate genomics and proteomics information with new approaches in computational biology.
How to cite this article:
Dr. Amitabha Kar, Dr. Partha Majumder and Debraj Nandi. An insight of a functional synapse - focused from a computational and experimental viewpoint. International Journal of Applied Research. 2019; 5(1): 163-167.