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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF
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Vol. 6, Issue 4, Part B (2020)
Study of the relationship between expression of Retinoic acid receptor: Beta by IHC in different grade of oral squamous cell carcinoma
Study of the relationship between expression of Retinoic acid receptor: Beta by IHC in different grade of oral squamous cell carcinoma
Author(s)
Abstract
In India Oral squamous cell carcinoma is the most common type of oral cancer (90%). The most common site of oral cancer is buccal mucosa. It has been observed that Vitamin A deficiency is associated with Squamous metaplasia in mucosa of upper aerodigestive tract. Present study intends to observe the estimate of Retinoic acid receptor-Beta expression in different grades of oral squamous cell carcinoma. Retinoic acid receptor-Beta expression is corelated with the grade of the tumor statistically.
In India Oral squamous cell carcinoma is the most common type of oral cancer (90%). The most common site of oral cancer is buccal mucosa. It has been observed that Vitamin A deficiency is associated with Squamous metaplasia in mucosa of upper aerodigestive tract. Present study intends to observe the estimate of Retinoic acid receptor-Beta expression in different grades of oral squamous cell carcinoma. Retinoic acid receptor-Beta expression is corelated with the grade of the tumor statistically.
Material and Methods: Study was conducted over a period of 2 year (Sep 2015-Sep 2017) on the specimen sent to pathology department of government medical college and hospital. It was studied histologically to assess the grade and then immunohistochemistry for RAR ß was performed.
Result: Study showed that 59.53% of cases belong to grade I followed by grade II (35.71) and grade III(4.76%).59.53% cases were positive for RAR ß and 40.47% cases were negative. There was significant association between grade of differentiation and status of RAR ß of the patients (p=0.0091). Proportion negativity of RAR ß increased with the increase in grade of differentiation.
Conclusion: A significant correlation was seen between the loss of RAR ß expression and advanced histopathological grade tumors of oral squamous cell carcinoma.
Pages: 90-92 | 666 Views 68 Downloads
How to cite this article:
Dr. Deepika Pandey, Dr. Saroj Kumar Singh, Dr. Hitesh Bucha, Dr. Gautam Mandal. Study of the relationship between expression of Retinoic acid receptor: Beta by IHC in different grade of oral squamous cell carcinoma. Int J Appl Res 2020;6(4):90-92.
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Research Journals