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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

Vol. 6, Issue 4, Part B (2020)

Impact of triclosan an antimicrobial agent on haematological parameters of fresh water fish Labeo rohita

Impact of triclosan an antimicrobial agent on haematological parameters of fresh water fish Labeo rohita

Author(s)
Nandagopalan Geetha and Naveena Priya
Abstract
Pharmaceuticals and personal care products are emerging as class â…¢ environmental pollutants. Among such pharmaceutical chemicals, Triclosan (TCS) is the most extensively used antibacterial agents, which inhibits the activity of bacteria, virus and fungi. From industrial effluents TCS reach aquatic ecosystem and accumulated in non- target aquatic organisms especially fish. Then, ultimately reach human beings through food chain. In the present study, toxic effect of triclosan on fresh water fish Labeo rohita was evaluated by estimating haematological parameters. Static bio- assay test was performed to determine the median lethal concentration (LC50) of TCS for 24hours, which was 0.9mg/L. Fish were exposed to sub-lethal concentration(0.09mg/L) for 15 days.
At stipulated time (5th, 10th & 15th day) haematological parameters were estimated. When compare to control group, there was a significant(p < 0.05) decrease in Haemoglobin (Hb) content, Erythrocyte count (RBC), Haematocrit (HCT) and Mean Corpuscular Volume (MCV) in TCS exposed fish, which indicates the disruptive action of TCS on erythropoitic tissues, causing shrinkage in RBC cells and making the erythrocytes more brittle and porous. Whereas significant ((p < 0.05) increase in Leucocytes count (WBC), Mean Cell Haemoglobin (MCH) and Mean Corpuscular Haemoglobin Concentration (MCHC) indicates the direct or indirect responses of structural damage in RBC membranes resulting in haemolysis. Bi-phasic response in WBC count may be due to stimulation in immune system in response to TCS, or hypoxia and gill damage due to accumulation of toxicant in gills, whereas at 15 th day WBC count was declined and the possible reason for such decline may be due to leucocytosis or non-specific decline in immunity (leucopenia) which are the characteristic response in animals exhibiting stress.
Pages: 118-123  |  774 Views  88 Downloads
How to cite this article:
Nandagopalan Geetha, Naveena Priya. Impact of triclosan an antimicrobial agent on haematological parameters of fresh water fish Labeo rohita. Int J Appl Res 2020;6(4):118-123.
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