Vol. 6, Issue 4, Part E (2020)

In present investigation, Escherichia coli isolates also exhibited a multi drug resistance to ampicillin, Penicillin, Nalidixic acid, Amoxicillin, Cefotexime, Norfloxacin and Tetracycline. This poses a threat to treatment of neonates due to increasing antibiotic resistance. Hence, this study of Escherichia coli causing neonatal sepsis and their sensitivity pattern is useful so that guidelines can be prepared for empirical antibiotic therapy. Molecular characterization of multi drug resistant Escherichia coli isolates by 16s rRNA analysis was confirmed. It is concluded multi-drug resistant E. coli has emerged as the predominant pathogen responsible for early-onset neonatal sepsis, particularly in preterm infants.