International Journal of Applied Research
Vol. 1, Issue 1, Part C (2014)
Efficacy of light based detection systems for early detection of oral cancer and oral precancerous lesion
Dr. Uddipan Kumar, Dr. Pragya Thakur and Dr. Jiji George
Carcinoma in an early stage of development is hard to detect clinically because the lesion may not be palpable and color of the lesional tissue is not necessarily different from the color of the surrounding mucosa. In order to improve the efficacy of the diagnosis, techniques are being developed to complement clinical examination and to facilitate the identification of initial carcinomas.
Aims: To find out the efficacy of chemiluminescent illumination (ViziLiteTM) for the diagnosis in precancer and cancer patients and compare this result to toluidine blue staining.
Materials and Methods: This study was done in 3 groups. Each group consists of 10 cases. Group I consists of normal appearing mucosa. Group II and III consist of clinically diagnosed precancer and clinically suggestive of cancer respectively. Chemiluminescent illumination, toluidine blue supravital staining and biopsy were performed in all cases. SPSS version 10.05 was used to calculate positive and negative predictive values.
Results: In Group I, all 10 patients showed negative result to ViziLiteTM. 8 patients showed positivity and 2 patients showed negativity to ViziLiteTM test in Group II. 9 patients were positive and one patient was negative for ViziLiteTM.
Conclusions: Chemiluminescent illumination test was sensitive for precancerous and cancerous lesions, which presented as keratotic lesions and red-white lesions. It showed negative result to erosive lesions. Toluidine blue staining test was reliable in precancerous and cancerous lesions, which present as erosive and red-white lesions. It showed negative result to keratotic lesions. These results indicate that chemiluminescent illumination test is relatively reliable and accurate than toluidine blue staining test and useful chair side diagnostic test.
How to cite this article:
Dr. Uddipan Kumar, Dr. Pragya Thakur, Dr. Jiji George. Efficacy of light based detection systems for early detection of oral cancer and oral precancerous lesion. Int J Appl Res 2014;1(1):142-144.