International Journal of Applied Research
Vol. 1, Issue 10, Part L (2015)
Integrative analysis of DNA microarrays in orofacial premalignant and malignant lesions (a review)
Introduction; Head and neck cancer is the sixth most common type of cancer worldwide; it constitutes a major health problem particularly in developing countries. Cancer biomarker plays very important role to detect possibility of transformation of premalignant to malignant, facilitate drug development, improve staging of patients, and predict patient prognosis. Because cancer is the result of many interacting genes, analysis based on a set of genes with related biological functions or pathways may be more informative than single gene-based analysis for cancer biomarker discovery. The relevant pathways thus identified may help characterize different aspects of molecular phenotypes related to the tumor. Conclusion: Present study helps to prevent transformation of premalignant lesion to malignant lesion and further morbidity by using cancer biomarkers.
How to cite this article:
Gouramma Padanad, Soujanya Reddy, Smrithi Devi Veera. Integrative analysis of DNA microarrays in orofacial premalignant and malignant lesions (a review). Int J Appl Res 2015;1(10):829-832.