Vol. 1, Issue 11, Part P (2015)

Regeneration process of the limb and finger regeneration following may be related to the age of host. When both stages of (prenatal and postnatal) were compared after surgical amputation regeneration ability in prenatal stage was found greater than the postnatal stage. Present study carried out using embryo culture technique shows that when the embryo's limb and finger was amputated at various proximo-distal levels and kept in a culture medium for 48 hours, there was repair and growth of skeletal muscle elements, as indicated by the accumulation of newly formed chondrocyte cells in the distal end of the amputated limb. Additionally, the Disto-proximal cut and finger stump showed a thin layer of wound epidermis covering the amputated surface of the stump. These findings suggest that there is some capacity for regeneration of amputated hindlimbs and fingers, although the extent of regeneration is limited. However, it is important to note that this study was conducted on prenatal mice and further research is needed to determine whether these findings apply to other mammalian species, including humans. Overall, this study provides valuable insight into the regenerative ability of neonatal mice limbs and highlights the need for further research in this area.