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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

International Journal of Applied Research

Vol. 1, Issue 12, Part P (2015)

A study on diagnostic value of GeneXpert MTB/RIF in sputum smear negative cases: A tertiary care hospital experience

Author(s)
Dr. Prasad Sudhir, Dr. Madire Ramulu and Dr. Chenimilla Nagender Prasad
Abstract
Background: Pulmonary tuberculosis (PTB) continues to be an important cause of preventable mortality in both developing and developed nations. The cornerstone of TB control remains early diagnosis and treatment. The tuberculosis continues to be one of the greatest killers in the world claiming over 1.5 million deaths in 2014.
Objectives: To study the diagnostic efficacy, the sensitivity, specificity, positive predictive value and negative predictive value of GeneXpert MTB/RIF and these results were compared with the results obtained by culture as reference.
Material & Methods
Study Design: Prospective cross-sectional study.
Study area: Dept. of. Respiratory Medicine, Prathima Institute of Medical Sciences, Karimnagar, Telangana.
Sample size: study consisted a total of 100 patients.
Sampling method: Simple Random sampling method.
Statistical Analysis: Statistical analysis was performed with SPSS software version 22 services. The analysis of categorical variables was examined by the chi-square test and Fischer’s test and value of P of <0.05 was considered significant for all statistical analysis.
Results: The sensitivity of GENEXPERT in Smear negative and Culture positive cases is 74.23%. The specificity of GENEXPERT in Smear negative and Culture positive cases is 90.26%. The PPV of GENEXPERT in Smear negative and Culture positive cases is 81.25%. The NPV of GENEXPERT in Smear negative and Culture positive cases is 86.76%.
Conclusion: GeneXpert is a rapid, reliable, attractive tool with least bio safety concern and requiring minimal training. It is best alternative to conventional methods of tubercular diagnosis which also detects rifampicin resistance simultaneously. And its efficacy is comparable to culture.
Pages: 1119-1122  |  59 Views  3 Downloads
How to cite this article:
Dr. Prasad Sudhir, Dr. Madire Ramulu, Dr. Chenimilla Nagender Prasad. A study on diagnostic value of GeneXpert MTB/RIF in sputum smear negative cases: A tertiary care hospital experience. Int J Appl Res 2015;1(12):1119-1122.
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