- Multidisciplinary Journal
- Printed Journal
- Indexed Journal
- Refereed Journal
- Peer Reviewed Journal
ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF
IMPACT FACTOR (RJIF): 8.4
Important Information
- Helpline for Authors
- India: +91-9711224068
- Toll Free (India):Â 18001234070
- Working hours: 10:00 AM-06:00 PM
Issue Bar
Side Bar
Identifier
Vol. 2, Issue 10, Part A (2016)
Immunomodulatory activity of black tea extract in rheumatoid arthritis: An in-vitro study
Immunomodulatory activity of black tea extract in rheumatoid arthritis: An in-vitro study
Author(s)
Abstract
Introduction: Rheumatoid Arthritis (RA) is an autoimmune disorder affecting approximately 1% of the population. The hallmark of RA is synovial inflammation along with bony erosion. Inflammation and associated oxidative stress are primary foci to design therapeutic strategies against RA. Black tea (BT) is a popular beverage. The Constituents of BT, mainly catechins & theaflavins, have been reported to have anti-oxidant, anti-inflammatory effects & used in various diseased conditions like cancer, Alzheimer’s disease etc. There is very scanty data on its effect on Rheumatoid arthritis. The study was designed to see the anti-inflammatory effect and anti-oxidative effect of black tea in RA
Introduction: Rheumatoid Arthritis (RA) is an autoimmune disorder affecting approximately 1% of the population. The hallmark of RA is synovial inflammation along with bony erosion. Inflammation and associated oxidative stress are primary foci to design therapeutic strategies against RA. Black tea (BT) is a popular beverage. The Constituents of BT, mainly catechins & theaflavins, have been reported to have anti-oxidant, anti-inflammatory effects & used in various diseased conditions like cancer, Alzheimer’s disease etc. There is very scanty data on its effect on Rheumatoid arthritis. The study was designed to see the anti-inflammatory effect and anti-oxidative effect of black tea in RA
Methods: Sixty Patients aged between 18-60yrs attending OPD, Department of Rheumatology, fulfilling ACR 1987 criteria with active disease and no prior use of steroids and anti-oxidants were recruited. Ten healthy controls were also recruited for the study. Levels of oxidative stress markers (total ROS, NO etc.) were measured in healthy controls and RA pt. Levels of inflammatory parameters (TNFα, IL6) were measured by standard ELISA kits.
Results: Markers of oxidative stress and inflammation showed strong positive correlation in RA patients with their disease progression and severity. BT extract significantly down regulated ROS generation (GMFC mean ± SD: 413.7±267.5 in untreated cells, 146.4 ±122.2 for cells treated with BT 250ng/ml, 166.8±120.9 for cells treated with BT 500ng/ml) and super oxide radical generation from activated neutrophils compared to BT untreated samples.BT extract significantly decreased NO production from activated PBMCs and also down regulated pro-inflammatory cytokine (TNFα, IL6) production from PBMCs as compared to BT untreated samples.
Conclusions: Black tea contributes significantly in lowering most of the oxidative stress and inflammatory parameters in RA patients. Thus BT may be used as a potent anti-oxidative therapeutic modality to control the oxidative stress and inflammation in RA patients.
Pages: 05-11 | 1374 Views 132 Downloads
How to cite this article:
Sampurna Roychoudhury Mazumder, Sanchaita Misra, Aharna Guin Paul, Dr. Pradyot Sinhamahapatra, Dr. Mitali Chatterjee, Dr. Alakendu Ghosh. Immunomodulatory activity of black tea extract in rheumatoid arthritis: An in-vitro study. Int J Appl Res 2016;2(10):05-11.
Important Information
- Helpline for Authors
- India: +91-9711224068
- Toll Free (India):Â 18001234070
- Working hours: 10:00 AM-06:00 PM
Issue Bar
Side Bar
Identifier
Research Journals