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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

International Journal of Applied Research

Vol. 2, Issue 10, Part A (2016)

Formulation and evaluation of Rasagiline floating tablets using HPMC

Author(s)
Syed Muneer, Srinivasa Rao D and Vijay K
Abstract
The aim of the present work was to develop a gastro retentive drug delivery system of Rasagiline with the objective of retarding the drug release when the dosage form is exposed to gastrointestinal fluid. Floating tablets of Rasagiline were developed using a HPMC K 250 PH PRM, HPMC K750 PH PRM, and HPMC K1500 PH PRM. The prepared tablets were evaluated in terms of their pre compression parameters, physical characteristics, In Vitro buoyancy, In Vitro drug release and release order kinetics. The results of In Vitro release studies showed that optimized formulation (F19) could sustain drug release (98.92%) for 24 h and remain buoyant for 24 h. The optimized formulation was subjected to various release kinetic investigations and it was found that the mechanism of drug release was predominantly diffusion with a minor contribution from polymeric relaxation. Floating tablets of Rasagiline were successfully formulated with the ability of providing controlled release and non-Fickian transport of the drug from tablets was confirmed.
Pages: 47-53  |  358 Views  7 Downloads
How to cite this article:
Syed Muneer, Srinivasa Rao D, Vijay K. Formulation and evaluation of Rasagiline floating tablets using HPMC. Int J Appl Res 2016;2(10):47-53.
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