Vol. 2, Issue 10, Part E (2016)

Abstract
The present study was conducted to determine the effect of orlistat on basal metabolic rate and biochemical parameters and liver enzymes in rabbits during the year 2015. Tetrahydrolipstatin commonly known as orlistat with a chemical formula (S)-2-formylamino-4-methyl-pentanoic acid (S)-1-[[(2 S, 3 S)-3-hexyl-4-oxo-2-oxetanyl] methyl]-dodecyl ester, is a lipstatin derivative which is gastric and pancreatic lipase inhibitor. It decreases caloric intake by inhibiting fats digestion and absorption. A 4-wk experiment was conducted using 20 females’ rabbits, 6-8yrs of age, to evaluate the effect of tetrahydrolipstatin on cholesterol, weight, glucose, uric acid and liver enzymes of rabbits. The rabbits were randomly distributed in to four groups. A, B, C and D. the grouping were based on the concentration of tetrahydrolipstatin add libitum to female rabbits. Group A was administrated with a standard control diet (control group). Group B, Group C and Group D received 120mg, 240mg and 360mg Tetrahydrolipstatin respectively, experiment duration was 31 days. Weight and cholesterol level was decreased significantly (P<0.01) while, other parameters were also differ significantly at the level of (P<0.05).It has been related to rare cases of acute liver injury.