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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

Impact Factor: RJIF 8.4

International Journal of Applied Research

Vol. 2, Issue 10, Part G (2016)

The effect of metformin on serum lipoprotein (a) levels and insulin resistance in South Indian women with polycystic ovary syndrome

Author(s)
Dr. Kandasamy Singaram, Dr. Inmozhi Sivagamasundari R, Dr. Bupathy A and Dr. Sethupathy S
Abstract
Aim: The study was done to determine the effect of metformin on lipoprotein (a) levels and insulin resistance in south Indian women with polycystic ovary syndrome.
Materials and Methods: A total number of 105 PCOS cases and 95 controls were recruited for the study. Base- line Parameters such as anthropometric, reproductive hormones, insulin resistance markers, and Lipoprotein (a) levels were measured by standard methods. All 104 PCOS cases received metformin 1500 mg/day for 8 weeks. At the end of 8 week treatment, insulin resistance was measured as HOMA-IR and serum lipoprotein (a) was measured by Immunoturbidimetric method by autoanalyzer.
Results: The results showed that there was significantly decreased in serum lipoprotein (a) levels (P<0.05) and Insulin resistance (P<0.01) by Metformin treatment.
Conclusion: The present study showed that Metformin treatment may cause the prevention of cardiovascular risk in south Indian women with PCOS by lowering Lipoprotein (a) levels and Insulin resistance.
Pages: 472-476  |  587 Views  13 Downloads
How to cite this article:
Dr. Kandasamy Singaram, Dr. Inmozhi Sivagamasundari R, Dr. Bupathy A, Dr. Sethupathy S. The effect of metformin on serum lipoprotein (a) levels and insulin resistance in South Indian women with polycystic ovary syndrome. Int J Appl Res 2016;2(10):472-476.
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