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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

Vol. 2, Issue 12, Part L (2016)

A study of serum uric acid levels in metabolic syndrome

A study of serum uric acid levels in metabolic syndrome

Author(s)
Dr. Akash Choudary and Dr. Mohd Ashraf Ul Abeddin
Abstract
Background: The relationships between uric acid and chronic disease risk factors such as metabolic syndrome, Diabetes, hypertension have been studied in adults. However whether these relationships exist in adolescents is unknown.
Metabolic syndrome is considered a collection of cardiovascular risk factors that generally includes central obesity, hypertension, high triglyceride and low HDL cholesterol levels. The prevalence of hyperuricemia has been increasing in recent years, not only in advanced countries but also in developing countries, along with the development of their economies. It has been suggested that hyperuricemia is associated with metabolic syndrome. Cardiovascular disease has been suggested to be associated with increased serum uric acid (UA) and with the components that contribute to metabolic syndrome.
Aims and Objectives:
1. To investigate the relationship between serum uric acid and metabolic syndrome.
2. To investigate the relationship between serum uric acid levels with the different components of metabolic syndrome.
Methods: 200 patients above the age of 18 years hospitalised in SIMS and RH satisfying the NCEP ATP III criteria for metabolic syndrome from October 2018 to August 2018 were taken for the study
Results: We studied a total of 200 patients of which 116 were females (58%) and 84 were males (42%) with a female: male ratio of 4:3. The mean age in our study was 116 for females and 108 for males. 63% of the patients were above the age of 50 years.
A mean uric acid level of 5.05±2.17 was seen in females and 5.92±2.44 in males. 68 (34%) of our subjects had elevated SUA levels with 36 females and 32 males. There was a prevalence of hyperuricemia in 38.1% of males and 31.1% of females. 73.5% of the patients with hyperuricemia were above the age of 50 years. The components of metabolic syndrome most commonly seen in females are high FBS levels, low HDL, high triglycerides and an increased waist circumference. The incidence of hypertension was the lowest among the components of metabolic syndrome. Increased serum uric acid levels had a direct positive statistical correlation with DBP and triglycerides with p values of 0.03 and 0.09 respectively.
The components of metabolic syndrome which were more commonly seen in males were elevated triglycerides, increased FBS and hypertension. Hyperuricemia was seen in 50% of patients with increased waist circumference. Elevated SUA levels had a definite statistical correlation with FBS and waist circumference with p values of 0.001 and 0.08 respectively.
Subjects with three, four and five components of metabolic syndrome had 32.1%, 32.5% and 37.5% incidence of hyperuricemia respectively.
Conclusion: We found hyperuricemia to be prevalent in patients with metabolic syndrome. There was a direct association between the components of metabolic syndrome and high serum uric acid levels. A statistical correlation was found between diastolic blood pressure and triglycerides with elevated uric acid levels in females. Increased serum uric acid levels had a significant statistical correlation with FBS and waist circumference. The incidence of hyperuricemia increased as the components of metabolic syndrome increased.
Pages: 852-857  |  218 Views  46 Downloads
How to cite this article:
Dr. Akash Choudary, Dr. Mohd Ashraf Ul Abeddin. A study of serum uric acid levels in metabolic syndrome. Int J Appl Res 2016;2(12):852-857.
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