International Journal of Applied Research
Vol. 2, Issue 8, Part C (2016)
Effect of cholesterol in the hydrolysis of oxidized phospholipids in different phosphatidyl choline membrane by PLA2
In humans oxidative stress leads to the development of certain class of cancer. Upon exposure of cell membranes to oxygen radicals obtained under oxidative stress, phospholipids are the most promissing substrates to oxidation as they owe oxidatively vulnerable polyunsaturated fatty acids predominantly at the sn-2 position. The oxidized phospholipids are suggested to be repaired by the action of phospholipase A2. It is because of PLA2 preferentially hydrolysis oxidized membranes over unoxidized membranes. PLA2 been hydrolysed PLPC-OOH on incorporation of different mole % of cholesterol into the Soy and egg phosphatidyl choline liposomal membrane. The study emphasizes that amount of cholesterol required for the hydrolysis of PLPC-OOH by PLA2 will be depending on the type and nature of availability of fatty acid on liposomal membrane.
How to cite this article:
MS Manjunath, Rajesh N, Abhijith M Singh. Effect of cholesterol in the hydrolysis of oxidized phospholipids in different phosphatidyl choline membrane by PLA2. Int J Appl Res 2016;2(8):177-181.