Vol. 2, Issue 8, Part C (2016)

Abstract
In humans oxidative stress leads to the development of certain class of cancer. Upon exposure of cell membranes to oxygen radicals obtained under oxidative stress, phospholipids are the most promissing substrates to oxidation as they owe oxidatively vulnerable polyunsaturated fatty acids predominantly at the sn-2 position. The oxidized phospholipids are suggested to be repaired by the action of phospholipase A₂. It is because of PLA₂ preferentially hydrolysis oxidized membranes over unoxidized membranes. PLA2 been hydrolysed PLPC-OOH on incorporation of different mole % of cholesterol into the Soy and egg phosphatidyl choline liposomal membrane. The study emphasizes that amount of cholesterol required for the hydrolysis of PLPC-OOH by PLA₂ will be depending on the type and nature of availability of fatty acid on liposomal membrane.