International Journal of Applied Research
Vol. 3, Issue 1, Part B (2017)
Study of KI 67 expression in carcinoma breast
Breast cancer is the second most common malignancy in India. It is a disease with unpredictable aggressiveness. Various treatment options are available for management of these patients. Many clinicopathologic prognostic factors play an important role in predicting responses to these treatment modalities. Commonly ER, PR and Her2/neu status is studied in all breast cancers. Of all the other markers, Ki 67 is one marker which reflects the proliferation potential of breast cancer. This can be used as an independent biomarker to know the response of tumor cells to chemotherapy. In the present study Ki 67 expression was studied and correlated to various clinicopathologic prognostic factors.
Aims and Objectives: Study of Ki 67 expression in breast cancer. To correlate Ki 67 expression with clinico pathological factors.
Methodology: 60 modified radical mastectomy specimens were studied. Histopathological examination followed by Immunohistochemistry study for Ki 67 expression was done and correlated with various clinicopathological factors.
Results: High Ki 67 expression was seen in 6(33%) cases in age group of 41- 50 years and all other age groups showed low expression of Ki 67. No statistically significant association between Ki 67 expression and age was noted in this study (p value=0.375). 3(5%) tumors with size < 2cms showed low expression of Ki 67 whereas 42(70%) cases with size > 2cms showed variable but high expression of Ki 67 and was statistically significant (p value = 0.002). Out of 18(30%) cases without lymph node involvement 17 showed low expression, 1 case showed high expression and out of 42(70%) cases with metastasis 38(90%) showed high expression (p value = 0.004). Grade 1 cases showed low expression Grade 2 and 3 cases showed high expression of Ki 67 which was statistically significant (p value = 0.022).
Conclusion: Ki 67 can be a valuable independent predictive and prognostic biomarker in breast cancer and it helps in management of these patients.
How to cite this article:
Dr. Sharath Kumar H.K, Dr. K. Shilpa, Geeta S. Study of KI 67 expression in carcinoma breast. Int J Appl Res 2017;3(1):98-100.