International Journal of Applied Research
Vol. 3, Issue 10, Part D (2017)
Incidence of neonatal sepsis and its causative agents
Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs and symptoms of infection in the first month of life. While most infection-related deaths in the neonatal period occur in low- and middle-income countries, there precise data have been lacking. The aim of the study was to determine the incidence and causative organisms for neonatal sepsis among infants and evaluate antibiotic resistance pattern of the organisms isolated. Total 228 clinically suspected cases were studied. Samples collected for culture were Blood, Umbilical swab and Skin swab. Identification and antimicrobial susceptibility testing of microorganisms was carried out by standard procedure. The male to female ratio in the study was not statistical significant. It was observed that babies died in low birth weight had maximum percentage of septicemia followed by very low birth weight, high risk low birth weight and normal birth weight. Male to female ratio showed significant difference with gestation age. Present study reported 39.9% cases to be blood culture positive. Klebsiella pneumoniae was found to be predominant organism followed by CoNS, Escherichia coli, Staphylococcus aureus and Candida albicans. Out of 189 cases, 67 infants showed bacterial growth in skin culture. The percentage of CoNS was maximum followed by Klebsiella pneumoniae, E. coli and Pseudomonas. The predominantly isolated pathogens in the study were CoNS, Klebsiella species, Escherichia coli, coagulase-positive staphylococci and least was Pseudomonas aeruginosa and Proteus vulgaris. Antibiotic susceptibility studies revealed the resistance pattern of pathogens isolated. Klebsiella pneumoniae isolates were resistant to chloramphenicol followed by Ceftriaxone, Ciprofloxacin and sensitive to Amoxyclav followed by Amikacin. E. coli isolates were mostly resistant to Chloramphenicol and Ciprofloxacin and sensitive to Amoxyclav and Amikacin. Isolates of S. aureus were resistant to Penicillin, and Oxacilline and most sensitive to Amoxyclav and Vancomycin. C. albicans isolated from blood culture were sensitive for Amphotericin B and Fluconazole. CoNS isolates were resistant to Penicillin and Oxacillin and most sensitive to Vancomycin and Amoxyclav. Most of the isolates of Pseudomonas aeruginosa were resistant to Ceftazidime, Cefoperazone and Tobramycin and sensitive to Amikacin, Ciprofloxacin and Ticarcillin. There cannot be single recommendations for the antibiotic regimen for neonatal sepsis in all settings. The choices of antibiotics depend on the prevailing flora responsible for sepsis in the given unit and their antimicrobial sensitivity. Determination of the neonatal sepsis incidence, its’ bacterial pathogens, and the patterns and rates of antibiotic resistance among all the neonate and infant populations are necessary.
How to cite this article:
Pravin Mishra, Dr. Shashikant Vaidya, Dr. Anagha Jayakar, Dr. Nandita Shinkre, Dr. Mamata Williamson, Dr. Geeta Koppikar. Incidence of neonatal sepsis and its causative agents. Int J Appl Res 2017;3(10):262-268.