Coagulative disorder is known to occur in the early phase of acute pancreatitis (AP) and D-dimer is a commonly used clinical parameter of haemostasis. The aim of this study was to assess the value of the plasma D-dimer level as a marker of severity in the days 1, 3, 5 after admission in patients with AP & to study the role of computed tomography in predicting the prognosis of acute pancreatitis & comparing D-dimer levels with Balthazar CT severity index in evaluation of severity of acute pancreatitis.
Method: From September 2015 to September2017, 60 patients admitted for AP were included in this observational study. The D-dimer level was measured on a daily basis during days 1, 3, 5 after admission. The maximum and the mean D-dimer values were used for analysis of multiple organ dysfunction syndrome (MODS), severity of pancreatitis Need for surgical intervention, outcome of disease. All the above variables are compared with CT severity index in predicting the severity of acute pancreatitis.
Results: Both the maximum and mean levels of D-dimer were signiﬁcantly different between patients with and without clinical variables such as multiple-organ dysfunction syndrome (MODS), severity of pancreatitis, need for surgical intervention, and outcome of disease. On comparing D dimer levels with CT severity index, CTSI is better in predicting the severity of acute pancreatitis.
Conclusion: D-dimer measurement is a useful, easy, and inexpensive early prognostic marker of the evaluation of severity of acute pancreatitis. CT severity index is better in predicting the severity of acute pancreatitis.