Contact: +91-9711224068
International Journal of Applied Research
  • Multidisciplinary Journal
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal

ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

International Journal of Applied Research

Vol. 3, Special Issue 3, Part H (2017)

Antihyperlipidemic activity of methanolic extract of flowers of Sphaeranthus indicus Linn. In rat

Author(s)
M Chopda, N Mahajan, BD Talele
Abstract
The present study was designed to investigate the Antihyperlipidemic activity of methanolic extract of Sphaeranthus indicus L. flower heads in atherogenic diet induced hyperlipidemia. Sphaeranthus indicus extract was administered in a dose of 250 and 500 mg/kg body wt. suspended in DMSO, p.o, for 7 days, after inducing hyperlipidemia. A marked increased in a level of serum cholesterol, triglycerides and LDL were found in the animals which received Triton-X 100 and HDL levels were decreased. Administration of methanolic extract of S. indicus at the dose of 250 and 500 mg/kg body weight shows significant reduction (**P<0.01 and ***P<0.001) in the level of serum cholesterol, triglycerides and LDL and increase in HDL level which was almost near to the standard Lovastatin. In accordance with these results, it may be confirmed that due to the presence of phyto constitutions such as flavonoids, steroids, saponons, glycosides and alkaloids in the methanolic extract of S. indicus at a dose of 250 and 500 mg/kg body weight exhibited significant hypolipidemic activity in Triton-X 100 induced hyperlipidemic rats
Pages: 236-238  |  968 Views  13 Downloads
download (185KB)
How to cite this article:
M Chopda, N Mahajan, BD Talele. Antihyperlipidemic activity of methanolic extract of flowers of Sphaeranthus indicus Linn. In rat. Int J Appl Res 2017;3(3S):236-238.
Call for book chapter
International Journal of Applied Research