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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

International Journal of Applied Research

Vol. 3, Special Issue 3, Part H (2017)

Inhibition of erythrocyte sickling in vitro by aqueous extracts of sphaeranthus indicus flowers and Ziziphus jujuba root

Author(s)
M Chopda, N Mahajan, S Chaudhari, S Pingale, P Mahajan, V Pawara
Abstract
Sickle cell disease (SCD) results from a mutation in the hemoglobin inside the red blood cells, where a glutamic acid at position 6 is replaced by a valine. Many phytomedicines have been identified as potential antisickling agents, stemming from reported usage as ethnomedicines by the local folk. In present study, aqueous extracts of Sphaeranthus indicus Flowers and Ziziphus jujuba Root for their possible antisickling activity was evaluated by spectrophotometrically. Both extracts caused significant (p<0.001) reduction in HbS polymerization. Aqueous extract of S. indicus (250 and 500μg/ml) at 120 sec showed maximum reduction in polymerization, 52.03 ± 0.14 and 62.40 ± 0.19% respectively. However, 1000 μg/ml aqueous extract of S. indicus at 90 sec exhibits highest reduction in polymerization, 65.83 ± 0.12. Aqueous extract of Z. jujuba (250 and 1000μg/ml) at 120 sec showed maximum reduction in polymerization, 61.53±0.20 and 72.90 ± 0.21% and 500 μg/ml aqueous extract of Z. jujuba showed maximum reduction 67.77 ± 0.22% at 150 sec. We conclude that aqueous extracts of Sphaeranthus indicus Flowers and Ziziphus jujuba Root are potential candidate for therapy and management of sickle cell disease.
Pages: 239-242  |  1037 Views  13 Downloads
How to cite this article:
M Chopda, N Mahajan, S Chaudhari, S Pingale, P Mahajan, V Pawara. Inhibition of erythrocyte sickling in vitro by aqueous extracts of sphaeranthus indicus flowers and Ziziphus jujuba root. Int J Appl Res 2017;3(3S):239-242.
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International Journal of Applied Research