Vol. 3, Special Issue 3, Part H (2017)

Abstract
The nephroprotective effect of polyherbal formulation (HM) in Albino wistar rats was studied. Rats were divided into six groups. Vehicle was administered to the group I (control). Nephrotoxicity was induced in the rats of group II by administering gentamicin (80mg/kg, i.p.) for 8 days. The HM (250,500 and 1000mg/k.g.p.o) was administered to the rats of group II and VI for 15 days together with gentamicin (8days). Kidney function was assessed by measuring urine urea and creatinine and serum urea and creatinine. Kidney superoxide dismutase, catalase were also measured in control and treated groups. Histopathological examinations were conducted to confirm the nephroprotective effect. The sign of nephrotoxicity in rats was significantly alleviated by herbal medicine. The results of histopathological examinations also confirm the nephroprotective effect of herbal medicine.