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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

International Journal of Applied Research

Vol. 3, Issue 6, Part J (2017)

Formulation and evaluation of dry suspension of taste masked coated pellets of cefixime

Author(s)
Mangesh R Bhalekar, Ashwini R Madgulkar, Rahul R Padalkar and Ahillya P Ohol
Abstract
The present study was aimed to mask the bitter taste of cefixime trihydrate and formulate it for pediatric use. Taste masking was done by multi-unit particulate pellet coating technology using R & D coater in two step process. Initially drug layering was done on sugar pellet followed by polymer coating on drug layered pellets as taste masked layer. Good efficiency of drug layering was observed with 0.45 gm HPMC E5 as a binder. Drug layered pellets were coated with different concentrations of methacrylate copolymer as taste masking polymer. The prepared taste masked pellets were evaluated for taste and drug content, leaching of drug. From in vitro taste evaluation, bitter taste of cefixime trihydrate was masked with 1.25 gm of Eudragit EPO.
Pages: 652-658  |  700 Views  18 Downloads
How to cite this article:
Mangesh R Bhalekar, Ashwini R Madgulkar, Rahul R Padalkar, Ahillya P Ohol. Formulation and evaluation of dry suspension of taste masked coated pellets of cefixime. Int J Appl Res 2017;3(6):652-658.
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International Journal of Applied Research