Vol. 3, Issue 6, Part J (2017)

Abstract
The present study was aimed to mask the bitter taste of cefixime trihydrate and formulate it for pediatric use. Taste masking was done by multi-unit particulate pellet coating technology using R & D coater in two step process. Initially drug layering was done on sugar pellet followed by polymer coating on drug layered pellets as taste masked layer. Good efficiency of drug layering was observed with 0.45 gm HPMC E5 as a binder. Drug layered pellets were coated with different concentrations of methacrylate copolymer as taste masking polymer. The prepared taste masked pellets were evaluated for taste and drug content, leaching of drug. From in vitro taste evaluation, bitter taste of cefixime trihydrate was masked with 1.25 gm of Eudragit EPO.