International Journal of Applied Research
Vol. 3, Issue 9, Part A (2017)
Optimization of crystallo- Co- Agglomerates of meloxicam-paracetamol to improve flow properties and dissolution
The purpose of this research was to obtain directly compressible agglomerates of Meloxicam-Paracetamol containing desired ratio of drugs using a crystallo – co- agglomeration technique. Crystallo-co-agglomeration is an extension of the spherical crystallization technique, which enables simultaneous crystallization and agglomeration of two or more drugs or excipients. Acetone-water system containing Polyvinylpyrrolidone (PVP) and Hydroxypropyl methyl- cellulose E5 (HPMC) as a additive were used in crystallization system. Acetone acted as a good solvent as well as bridging liquid for Meloxicam-Paracetamol for agglomeration. Meloxicam was crystallized from acetone and agglomerated with Paracetamol. Excipient compatibility study was carried out by FTIR. Selection of polymer is carried out by drug content, flow properties, % drug release and Heckel analysis. The optimization of formulation of selected polymer was carried out by using 23 factorial design. Where the factors were speed of rotation, polymer: drug ratio and amount of bridging liquid. The responses evaluated were % drug release, MYP and carrs index. Evaluation of optimization was carried out. The compatibility study for optimized batch and pure drug was done by powder X ray difractometry (PXRD), FTIR and surface morphology was done by scanning electron microscopy (SEM) The result revealed that micromeritic properties (angle of repose 19.73-28.070, % compressibility 9-17 and Hauser ratio between 1.08-1.20 and compactibility (mean yield pressure 1.08-3.99 tonns) of agglomerates of PVP enabled direct compression without any defect. PXRD showed no change in crystalline form of drug and SEM demonstrated spherical and smooth surface. In vitro dissolution study revealed that varying the polymer concentration prolongs the drug release. From the results, the conclusion is that crystallo-co-agglomeration technique is a suitable alternative method to the granulation process and can be used for design of immediate release Meloxicam-paracetamol agglomerates with varying concentration of polymer.
How to cite this article:
Trupti D Dongare, Mangesh R Bhalekar, Santosh V Gandhi. Optimization of crystallo- Co- Agglomerates of meloxicam-paracetamol to improve flow properties and dissolution. Int J Appl Res 2017;3(9):34-39.