International Journal of Applied Research
Vol. 4, Issue 11, Part B (2018)
Comparison of sublingual and vaginal misoprostol on cervical priming prior to vacuum aspiration in first trimester abortion at tertiary care hospital
world-wide more than 40 million abortions are occurred each year, more than two third of these abortions occur during the first trimester of pregnancy. Vacuum aspiration is the method of choice for the first trimester abortions and is one of the commonly performed surgical procedures. Cervical priming prior to vacuum aspiration facilitates the procedure, decreases the risk of cervical injury and uterine perforation by making the cervix softer and easier to dilate.
To compare the efficacy and side effects of sublingual and vaginal misoprostol on cervical priming prior to vacuum aspiration in first trimester abortions.
Material & Methods:
It was a hospital based prospective randomised trial. A total of 160 pregnant women between 6-13 weeks of gestation who opted for termination of pregnancy either because of failed contraception, USG findings suggestive of missed abortion or blighted ovum were taken into study & divided into sublingual and vaginal group. Single dose of 400 micrograms of misoprostol was administered either sublingual or vaginal route 3-4 hours before the procedure. The outcome measures compared were cervical dilatation before vacuum aspiration, duration of the procedure, intraoperative blood loss and preoperative side effects.
Results: The mean cervical dilatation of subjects in the sublingual group was significantly higher than the vaginal group (6.9 + 2.12 mm vs 4.96 + 1.4 mm, p= 0-002). The mean duration of the procedure was significantly lower compared to the vaginal group (2.62 + 0.84mt Vs 3.17 + 0.74mt, p=0.001). The intra operative blood loss was slightly higher in the sublingual group compared to the vaginal group ( 40.61 + 5.1 ml Vs 32.84 + 6.04 ml) but the difference was statistically not significant (p=0.68). The preoperative side effects like vomiting, abdominal pain, fever, diarrhoea and rigours were less in the sublingual group compared to vaginal group.
Conclusion: Sublingual misoprostol is more effective with good patient acceptability than vaginal misoprostol for cervical priming prior to vacuum aspiration in first trimester abortions.
How to cite this article:
Dr. Bhargavi Bandi, Dr. Seshasai Tirupati, Dr. Sukanya Seshasai. Comparison of sublingual and vaginal misoprostol on cervical priming prior to vacuum aspiration in first trimester abortion at tertiary care hospital. Int J Appl Res 2018;4(11):83-86.