Vol. 4, Issue 12, Part B (2018)

Abstract
Recurrent foetal loss (RFL) is a serious and potentially devastating health problem. It appears that autoantibodies serve as major risk factor, leading to foetal loss but not much work is available on role of autoantibodies in Indian women. Hence, study was carried out to ascertain roleof increased autoantibodies levels to RFL in Nair Hospital, Mumbai. Study comprised of 143 women in study group having history of RFL and 140 women in control group. Anticardiolipin antibodies (ACA) and Antinuclear Antibodies (ANA) and Lupus Anticoagulant (LA) giving prolonged “Activated Partial Thromboplastin Time” tests were carried out by the kits. Incidence of autoantibodies was found only in study group, as compared to control group. The incidence of ACA (31.47%), ANA (15.22%) and LA (19.33%) in study group was found to be highly significant. (p<0.001). The data shows a high percentage of ACA IgG (30.07%) as compared to ACA IgM (22.38%), Out of 143 women investigated for ACA, 45 (31.46%) women had ACA IgG and /or IgM antibodies, while 20.98% women showed ACA IgG and IgM both. The incidence of total APA (34.96%) was higher as compared to ANA (15.22%), while the occurrence of both APA and ANA was relatively low (8.69%).A statistically significant incidence of elevated autoantibody level was found only in the women with a history of RFL as compared to clinically normal women. Thus, elevated levels of autoantibodies played a significant role in failure of pregnancy.