Vol. 6, Issue 10, Part F (2020)

Abstract
The objective of the present study was to synthesize new pyrimidine substituted 1,3,4-oxadiazole derivatives and evaluate them for antimicrobial and anti-inflammatory activities. Novel pyrimidine substituted 1,3,4-oxadiazole derivatives (11a-k) were synthesized from the condensation of different substituted aromatic carboxylic acids with substituted pyrimidine carboxy hydrazide using POCl₃ as condensing agent. Their structures were characterized by physical and spectral studies. The synthesized compounds were evaluated for their in vitro antimicrobial and anti-inflammatory activity. Some of the newly synthesized compounds showed good antimicrobial and anti-inflammatory activities.