Vol. 6, Issue 4, Part D (2020)
Comparison of serum homocysteine level with the risk factors of stroke: A prospective study
Comparison of serum homocysteine level with the risk factors of stroke: A prospective study
Author(s)
Dr. Shailendra Singh, Dr. Chetan Mathur, Dr. Hritu Singh and Dr. Shahid Abbas
AbstractBackground: Stroke is one of the leading causes of mortality and morbidity worldwide. Approximately 20 million people each year suffer from stroke and of these 5 million do not survive.
Aims and Objective: to compare the serum homocysteine level among the groups and compare it with the presence of hypertension, diabetes and smoking status.
Materials and Methods: Ninety subjects were studied in the Department of General Medicine at Sri Aurobindo Medical College and PGI, Indore (M. P.) for one and half year from June-2015 to March-2016 after dividing them in to Cases (n=45; patients of ischemic stroke) and Control (n=45; subjects with no documented stroke). After recording general information on smoking/alcohol habit, hypertension and diabetes status, serum homocysteine level was assessed in all the subjects.
Results: Mean homocysteine level (37.75±9.39 μmol/L) was greater in Case group as compared to Control group (11.79±1.64 μmol/L) (p<0.001). Amongst those who had a stroke but had a habit of smoking/tobacco, had hypertension and diabetes diagnosed with high mean Homocysteine level (54.01±0.00 μmol/L, 41.08±1.25 μmol/L and 35.88±8.65 μmol/L) as compared to those without stroke. That patient had mixed diet detected with raised Homocysteine as compared to those patients whose type of diet was vegetarian.
Conclusion: Hyperhomocysteinemia appears to be an important risk factor for cerebrovascular accidents.
How to cite this article:
Dr. Shailendra Singh, Dr. Chetan Mathur, Dr. Hritu Singh, Dr. Shahid Abbas. Comparison of serum homocysteine level with the risk factors of stroke: A prospective study. Int J Appl Res 2020;6(4):232-235.