International Journal of Applied Research
Vol. 6, Issue 6, Part F (2020)
Evaluation of analgesic activity of t type calcium channel blocker (ethosuximide) in animal model of neuropathic pain
Background: Neuropathic Pain is recognized as one of the most difficult type of pain to treat with conventional analgesics. Several evidence implicate that T-type VGCC in Pathophysiology of neuropathic and inflammatory pain. Ethosuximide, a T type VGCC blocker thus can be useful in Neuropathic Pain. Objectives 1. To evaluate the analgesic activity of Ethosuximide in Normal rats. 2. To evaluate the analgesic activity of Ethosuximide in Vincristine induced animal model of neuropathic Rats. Material & Methods Drugs: Ethosuximide, Vincristine. Animals: Adult albino rats (wt.180-200gms, of either sex) were divided in 5 groups of ten rats in each group. Group 1 was Normal rats: Group 2 was vehicle treated group; Group 3 was Vincristine induced neuropathy; Group 4 was given Different doses of Ethosuximide intraperitoneally on different days in Normal rats; Group 5 was neuropathy-induced rats who were given different doses of Ethosuximide i.p on different days. Evaluation of analgesic activity of Ethosuximide was carried out by using acetone drop method (ADM), cold Tail immersion test (TIT), hot plate method (HPM) in Normal and neuropathy induced rats. Results: Ethosuximide (95 mg/kg, 125 mg/kg, 155 mg/kg, 190 mg/kg &220 mg/kg, i.p) was effective in alleviating Thermal algesia in Normal rats (HPM, TIT).There was no Allodynia. Cold Allodynia and thermal Hyperalgesia were exhibited after ten days of Vincristine administration (50mcg/kg, daily, i.p, 10days). Intraperitoneal administration of Ethosuximide (95 mg/kg, 125 mg/kg, 155 mg/kg, 190 mg/kg &220 mg/kg) attenuated the thermal Hyperalgesia (TIT, HPM) in dose dependent manner in Neuropathic rats. It also alleviated cold Allodynia (ADM) in Neuropathic rats. Conclusion: Ethosuximide has analgesic activity in acute pain model. It is also effective in relieving thermal Hyperalgesia and cold Allodynia in Vincristine induced neuropathic pain in rats.
How to cite this article:
Dr. Vijayendra Gautam, Dr. Devendra S Doneriya. Evaluation of analgesic activity of t type calcium channel blocker (ethosuximide) in animal model of neuropathic pain. Int J Appl Res 2020;6(6):335-339.