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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

International Journal of Applied Research

Vol. 7, Issue 7, Part C (2021)

Synthesis, characterisation, docking studies and anti-microbial evaluation of ethyl (4-substituted phonoxy)-benzodioxophosphol-4-oxothiazolidin-thiophene-2-carboxylates

Author(s)
YN Spoorthy, P Vijaya Kumar, T Sailaja Rani and LK Ravindranath
Abstract
The reaction of ethyl 3-((3,4-dimethoxybenzylidene)amino) thiophene-2-carboxylate (5) reacts with mercapto acetic acid in presence of zinc chloride in dioxane forms ethyl 3-(2-(3,4-dimethoxyphenyl)-4-oxothiazolidin-3-yl)thiophene-2-carboxamide (6) which on hydrolysis affords the ethyl 3-(3-chloro-2-(3,4-dihydroxyphenyl)-4-oxothiazolidin-3-yl)thiophene-2-carboxylate (7). A new series of ethyl (4-substituted phonoxy)-benzodioxophosphol-4-oxothiazolidin-thiophene-2-carboxylates (9a-g) were synthesized from ethyl 3-(3-chloro-2-(3,4-dihydroxyphenyl)-4-oxothiazolidin-3-yl)thiophene-2-carboxylate (7) by condensing with 4-substituted phenyl phosphoro dichloridates (8a-g). The structures of these analogues (9a-g) have been established by 1H NMR, IR, Mass spectral data and elemental analysis. This study describes the anti-microbial activity and docking studies of newly synthesized analogues (9a-g).
Pages: 196-203  |  248 Views  7 Downloads
How to cite this article:
YN Spoorthy, P Vijaya Kumar, T Sailaja Rani, LK Ravindranath. Synthesis, characterisation, docking studies and anti-microbial evaluation of ethyl (4-substituted phonoxy)-benzodioxophosphol-4-oxothiazolidin-thiophene-2-carboxylates. Int J Appl Res 2021;7(7):196-203. DOI: 10.22271/allresearch.2021.v7.i7c.8756
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