Vol. 8, Issue 1, Part F (2022)

Inflammatory effects of pyrimidines are attributed to their inhibitory response versus the expression and activities of certain vital inflammatory mediators namely prostaglandin E2, inducible nitric oxide synthase, tumour necrosis factor-α, nuclear factor κB, leukotrienes, and some interleukins. Literature studies reveal that a large number of pyrimidines exhibit potent anti-inflammatory effects. SARs of numerous pyrimidines have been discussed in detail. Several possible research guidelines and suggestions for the development of new pyrimidines as anti-inflammatory agents are also given. Detailed SAR analysis and prospects together provide clues for the synthesis of novel pyrimidine analogy possessing enhanced anti-inflammatory activities with minimum toxicity. The trease5rcher found that Inflammation is biological feedback of the immune system that is initiated by several toxic stimuli, namely, microorganisms, chemical irritants, damaged cells, and noxious compounds. Inflammation acts via the elimination of all these harmful stimuli, and thus triggers the process of tissue repair. Nevertheless, chronic inflammations can cause severe disorders, for example, diabetes, hepatitis, asthma, cardiovascular diseases and rheumatoid arthritis.