Vol. 8, Issue 3, Part A (2022)

Abstract
National anti-Brucella Serum Reference Standard is necessary to ensure that a given antibody assay is capable of measuring antibody activity to a specified level of diagnostic sensitivity. Diagnostic sensitivity relates to the risk of a false negative reaction occurring in an antibody assay when in fact an animal is, or has been, infected. At the same time, plate agglutination test, used for differentiation of the unknown isolates during bacteriology of suspected biomaterials, needs reliable serum capable to reveal and determine antigens of the bacteria. Taking into account the fact that first isolates of brucella cultures can be dissociated to other form than typical “S-form” the first national anti-brucella serum standard against S, R, SR and RS forms of Brucella is developed and tested.