Vol. 8, Issue 3, Part A (2022)

Abstract
Currently two vaccines from strains B. abortus 19 and B. melitensis Rev 1 are widely used for immune prophylactic of animal brucellosis. Using of strain Rev 1 vaccine is restricted due to its reactogenicity, frequent abortions and long time persistence of agglutinins in blood serum (up to 3-5 years) that result in false positive tests during serological diagnostics. Vaccine from B. abortus strain 19 is not reactogenis and does not cause abortions. On small ruminants this vaccine is used by full doses (40 bn microbe bodies, m.b.) on the following scheme: at 3-5-month age, before insemination and further each year in the same doses. However, in so doing this vaccine stimulate high agglutinins titers in blood that impede conducting of reliable diagnostics and cause organism sensitization. It was established that application of reduced dose of the vaccine B. abortus strain 19 against the background of full dose vaccination enables to avoid long time agglutinin persistence in serum of small ruminants and provide the same immunity strength as in full dose vaccinated. This make it possible to save considerable amount of means spend for vaccines purchase and to avoid undesirable effects emerging in using of full doses on small ruminants.