Vol. 8, Issue 3, Part F (2022)
Mechanisms of ß-lactam resistance among Pseudomonas aeruginosa
Mechanisms of ß-lactam resistance among Pseudomonas aeruginosa
Author(s)
Dr. Krishna Kumar Patel and Dr. Sarita Patel
Abstract
A total of 100 clinical isolates of Pseudomonas aeruginosa from inpatient and outpatient were isolated from various clinical samples from January 2021 to December 2021 in a tertiary care hospital in Bilaspur, Chhattisgarh. Uropathogenic P. aeruginosa infections were more prevalent in females than in males. Ciprofloxacin, Piperacillin, Imipenem were found more effective for treatment of infections in outpatients but for inpatients, parental therapy with newer aminoglycosides and third and fourth generation cephalosporins were found to be effective. About 99% of the clinical isolates were resistant to six commonly used antibiotics- ampicillin (100%) and cefuroxime (100%), amoxicillin (99%), co-trimoxazole (99%), Tetracycline (99%), cefazoline (99%). In vitro sensitivity pattern of 100 isolates of P. aeruginosa showed hight sensitivity to imipenem (97%), amikacin (79%), tobramycin (70%), ceftazidime (62%), ciprofloxacin (73%), cefoperazone (60%), piperacillin (65%), gentamycin (34%) and cefotaxime (14%). ESBL producing strains (33%) were more resistant to beta-lactams and other antibiotics. The results indicate that P. aeruginosa is commonly responsible for the nosocomial infections in Jagdalpur.
How to cite this article:
Dr. Krishna Kumar Patel, Dr. Sarita Patel. Mechanisms of ß-lactam resistance among Pseudomonas aeruginosa. Int J Appl Res 2022;8(3):479-482.