Vol. 9, Issue 8, Part D (2023)

Analyzing the in vivo antioxidant activity in mice is
fundamental in elucidating the physiological relevance and therapeutic
potential of antioxidant compounds. Oxidative stress, stemming from the
imbalance between reactive oxygen species (ROS) generation and antioxidant defense
mechanisms, underlies the pathogenesis of numerous diseases, including cancer,
cardiovascular ailments, and neurodegenerative disorders. This abstract
underscore the importance of in vivo studies in preclinical research and
drug development, particularly focusing on mice as valuable experimental
models. Mice offer genetic similarity to humans, facile handling, and a
plethora of genetic and pharmacological tools for mechanistic inquiries.