Vol. 10, Issue 10, Part B (2024)

Abstract
The effect of steroidal and non-steroidal contraceptive oral pill on the blood serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase, acid phosphatase, and alkaline phosphatase enzymes was carried out in wistar female albino rats weighing about 125 g ± 2 g. The steroidal combined oral contraceptive pill (norgestrel + ethinylestradiol) was diluted to 0.14 mg/ ml (Low Dose), 0.21 mg/ml (dose as per literature), and 0.43 mg/ ml (high dose). The non-steroidal oral contraceptive pill (Centchroman) was diluted to 0.29 mg/ ml (Low Dose), 0.43 mg/ml (dose as per literature) and 0.87 mg/ml (high dose). In present study, Acid phosphates as well as alkaline phosphatase was decreased significantly except in rats fed with 0.29 mg/ml/rat/ day dose, serum alkaline phosphatase was found to be increased significantly. Similarly, SGOT was decreased significantly in rats fed with the steroidal pills. In case SGPT in both the cases of experimental rats at low and medium doses significantly elevation was noted after 30 days, however, at higher dose a significant lowered SGPT was seen. In this study both steroidal and non-steroidal contraceptives have obvious effects on serum enzymes. More research is needed to calculate the perfect dose which to avoid permanent effects of these drugs.